In order to reduce the synthesis time of tris⁃(4⁃acetamidphenyl) methane and increase its yield, the reaction environment was transferred to ultrasonic waves, and ultrasonic wave shaking was used instead of the water bath stirring heating method. The infrared micro⁃spectroscopy was used to analyze whether acetamide was formed in the product; the high⁃performance liquid chromatography⁃mass spectrometer was used to analyze the conversion of the reactants at different time, temperature and reactant ratios and the yield and composition of the reaction product tris⁃(4⁃acetamidophenyl) methane. Further, the purified tris⁃(4⁃acetamidophenyl) methane was detected and confirmed using a Fourier transform nuclear magnetic resonance spectrometer. The results show that the reaction environment can be set in the ultrasonic wave, which can not only greatly reduce the reaction time, but also reduce the formation of by⁃products; improve the product yield, reduce energy consumption and avoid environmental pollution.